Organic Acids: Gut Microbiome Test (Candida, Metabolic & Vitamins)

The Organic Acids Test (OAT) by MosaicDX (formerly Great Plains Lab) is a straightforward and effective method for evaluating various metabolic pathways, shedding light on imbalances and nutritional requirements. This test examines 76 organic acids in a single urine sample, providing valuable insights for individuals grappling with complex chronic conditions.

Individuals with chronic illnesses and neurological disorders often excrete abnormal organic acids in their urine. Contributing factors to these elevated levels may include oral antibiotic usage, immune deficiencies, high sugar diets, infections, and genetic factors.

Metabolic processes in the body produce organic acids through the digestion of proteins, carbohydrates, and fats. These acids play a vital role in generating cellular energy and supplying essential components crucial for cellular function.

Organic acids are chemical compounds produced during metabolism and excreted in urine.

Assessing organic acids offers a means for us to functionally evaluate patients' nutrient status. Elevated levels of organic acids in urine may indicate metabolic inhibition or blockage due to an inherited enzyme deficiency, nutrient deficiency, toxic accumulation, or the effects of medication.

Enzymes responsible for metabolizing organic acids rely on vitamins and minerals for proper functioning. Therefore, an increase in organic acids in urine may signal a functional requirement for these nutrients at a cellular and biochemical level, even if serum analysis yields normal results.

Test results can guide us in recommending the best nutrient supplement strategies

+ A first-in-the-morning urine sample is required for the test.

+ Fasting is needed overnight (collect 1st morning urine)

+ Patients should avoid apples, grapes, raisins, pears, cranberries, and their juices, arabinogalactan, reishi mushrooms, echinacea, and ribose supplements for 48 hours prior specimen collection

Adipic Acid
Vanillylmandelic Acid
Pyruvic Acid
Pyroglutamic Acid
Kynurenic Acid
Malic Acid
Glycolic Acid
Orotic Acid
Citric Acid
Oxalic Acid
Lactic Acid
Glyceric Acid
Methylmalonic Acid
Suberic Acid
3-OH-3-Methylglutaric Acid
Dihydroxyphenylpropionic Acid
Succinic Acid
Ascorbic Acid
Glutaric Acid
Pyridoxic Acid
3-Hydroxyglutaric Acid
3-Methylglutaric Acid
Malonic Acid
N-Acetylaspartic Acid
4-Hydroxyphenyllactic Acid
Homogentisic Acid
Pantothenic Acid
Phenylpyruvic Acid
Phenyllactic Acid
Mandelic Acid
2-Oxo-4-methiolbutyric Acid
2-Hydroxyisocaproic Acid
3-Methyl-2-oxovaleric Acid
2-Oxoisovaleric Acid
2-Hydroxyisovaleric Acid
2-Hydroxyhippuric Acid
2-Oxoisocaproic Acid
5-Hydroxymethyl-2-furoic Acid
3-Oxoglutaric Acid
Furan-2,5-dicarboxylic Acid
Furancarbonylglycine
Tartaric Acid
Arabinose
Carboxycitric Acid
Tricarballylic Acid
2-Hydroxyphenylacetic Acid
Methylcitric Acid
4-Hydroxyphenylacetic Acid
4-Hydroxybenzoic Acid
4-Hydroxyhippuric Acid
Hippuric Acid
3-Indoleacetic Acid
3-(3-hydroxyphenyl)-3-hydroxypropionic Acid
4-Cresol
2-Hydroxybutyric Acid
Fumaric Acid
2-Oxoglutaric Acid
Aconitic Acid
HVA/VMA Ratio
5-Hydroxyindoleacetic Acid
Quinolinic Acid
HVA/DOPAC Ratio
Dihydroxyphenylacetic Acid
Uracil
Thymine
3-Hydroxybutyric Acid
Acetoacetic Acid
4-Hydroxybutyric Acid
Ethylmalonic Acid
Methylsuccinic Acid
Sebacic Acid
Phosphoric Acid
3-Methylglutaconic Acid
N-Acetyl Cysteine
Homovanillic Acid
Citramalic Acid

Common symptoms and diseases associated with nutritional deficiencies and other metabolic imbalances include:

1. Anxiety - Emotional and mental health disturbances.

2. Autism Spectrum Disorders - Developmental disorders affecting communication and behavior.

3. Depression - A mood disorder characterized by persistent feelings of sadness and loss of interest.

4. Diabetes - A metabolic disease that causes high blood sugar.

5. Digestive Disorders - Issues affecting the gastrointestinal system.

6. Fatigue - Persistent tiredness or weakness.

7. Fibromyalgia - A condition characterized by widespread musculoskeletal pain.

8. Gastrointestinal Dysbiosis - Imbalance in the microbial communities in the digestive tract.

9. Insulin Resistance - A condition where cells in the body don't respond effectively to insulin.

10. Neurological Disorders - Diseases of the brain, spine, and the nerves that connect them.

11. Obesity - Excessive body fat that presents a risk to health.

12. Psychological Disorders - Disorders that affect mood, thinking, and behavior.

13. Vulvodynia - Chronic, unexplained pain in the area around the opening of the vagina.